Mankhwala opopera pakamwa/pakhosi (2022)

Katundu wachilengedwe wa carrageenan poyambilira adafufuzidwa ngati chophatikizira kuti apange kusasinthika koyenera kwa utsi kuti apereke mamolekyu okwera mtengo achilengedwe, decorin ndi resolvin mkati mwa kamwa. Komabe, carrageenan inapezeka kuti ili ndi mphamvu zotsutsana ndi zipsera zake. Ndi yotsika mtengo, yotetezeka komanso yopezeka mosavuta, yochokera ku udzu wa m'nyanja ndipo imagwiritsidwa ntchito muzakudya zambiri. Mosiyana ndi mamolekyu achilengedwe omwe amafunikira chisamaliro chapadera kuti asungunuke muutsi ndikusunga machiritso awo, kutsitsi kwa carrageenan kumakhala kokhazikika komanso kosavuta kukonzekera.

Ofufuzawo amakhulupirira kuti carrageenan blended spray ingathandize kuchepetsa zipsera m'kamwa mwa anthu omwe ali ndi EB poyimitsa maselo a m'kamwa kukhala maselo owopsa, kuletsa minofu ya chilonda kuti isapangidwe mofulumira komanso chifukwa cha mafuta ake kuti achepetse kukangana poyankhula ndi kudya. Ntchitoyi imatifikitsa pafupi ndi kutsitsi pakamwa kuti tichite zizindikiro za EB.

Ofufuza zotsatira zofalitsidwa za ntchito yawo yopopera mankhwala kuti achepetse matenda a Covid mu 2021 ndikupereka zotsatira pa Sabata la 2022 la Amembala a DEBRA UK:

Mtsogoleri wa kafukufuku:

Liam Grover ndi Pulofesa mu Biomaterials Science ndi Mtsogoleri wa Healthcare Technologies Institute ku yunivesite ya Birmingham UK. Healthcare Technologies Institute imasonkhanitsa akatswiri otsogola ochokera m'machitidwe osiyanasiyana ku Yunivesite ya Birmingham kuti apititse patsogolo ukadaulo watsopano ndi mankhwala omwe amalimbikitsa machiritso abwino a minofu ndi zida zokonzanso.

Ofufuza nawo: 

Tony Metcalfe ndi Pulofesa wa Kuchiritsa Mabala ku Yunivesite ya Birmingham. Tony wagwira ntchito m'masukulu, m'mafakitale komanso m'magawo osapeza phindu ndipo cholinga chake pakufufuza ndikukonzanso minofu, mankhwala omasulira komanso machiritso opanda zipsera.

Iain Chapple ndi Pulofesa wa Periodontology ndi Mtsogoleri wa Sukulu ya Udokotala Wamano ku Yunivesite ya Birmingham UK ndi Katswiri mu Udokotala Wobwezeretsa Mano. Amatsogolera gulu lolimba monga gawo la Birmingham's Periodontal Research Group, ndipo ndi Director of Research for Institute of Clinical Sciences ku yunivesite ya Birmingham. Iain amayendetsa ntchito yachipatala yapakamwa ndi yamano kwa odwala achikulire a EB mogwirizana kwambiri ndi Adrian Heagerty, Consultant Dermatologist ndi katswiri wa EB, ndipo akutsogolera polojekiti yothandizidwa ndi DEBRA UK kuti amvetse zambiri za khungu la microbiome mu EB.

Adrian Heagerty ndi Consultant Dermatologist pa University Hospitals Birmingham NHS Trust komanso ndi Pulofesa Wolemekezeka wa Dermatology pa Institute of Inflammation and Aging pa yunivesite ya Birmingham. Prof Heagerty pakali pano akugwira ntchito zofufuza zingapo kuti apititse patsogolo moyo wa anthu omwe akudwala EB.

Wothandizira:

Prof Alan Smith, Mtsogoleri wa Biopolymer Research Center, University of Huddersfield

“Ndife okondwa kulandira ndalama za DEBRA za polojekiti yathu. Izi zitithandiza kupanga makina athu operekera utsi omwe tikukhulupirira kuti angathandize kwambiri odwala omwe ali ndi epidermolysis bullosa "

Pulofesa Liam Grover

“Ndife othokoza kwambiri a DEBRA chifukwa cha thandizo lawo popereka ndalama zothandizira ntchito yotulutsa utsi. Tikukhulupirira kuti zotsatira za polojekitiyi zipititsa patsogolo mwayi wopereka mamolekyu achire mkamwa ndikusintha moyo wa odwala omwe ali ndi epidermolysis bullosa. "

Pulofesa Tony Metcalfe

Grant Title: Njira yatsopano yoperekera utsi pochiza mabala a mucosal mu epidermolysis bullosa.

Ntchitoyi idzagwira ntchito popanga njira yatsopano yoperekera utsi monga njira yochizira komanso yodzitetezera ku zipsera zomwe zimakhudza mucosa kapena nembanemba m'thupi lomwe limadziwika ndi EB, komanso kudwala komwe kumachitika. Cholinga chonse chidzakhala kupanga dongosolo loperekera izi kuti lizigwiritsidwa ntchito popereka ma molekyulu atatu odana ndi fibrotic. Chofunika kwambiri, kutulutsa komaliza kwa polojekitiyi kudzakhala machitidwe atatu opangidwa ndi kupangidwa m'njira yomwe ingalole kuti agwiritsidwe ntchito poyerekezera ndi mayesero achipatala, omwe adzalipidwa ndi malonda kapena kudzera mu ntchito yowonjezera yowonjezera.

Zolinga zonse za polojekitiyi zidzakhala:

1. Pangani, ndi asing'anga ndi magulu a odwala, kupopera pakamwa komwe kungagwiritsidwe ntchito poperekera ku mphuno (pa tsaya).
2. Imwani mamolekyu achire a antifibrotic m'nkhaniyi ndikuwonetsa mphamvu zawo zochizira panthawi yosungira ndikupopera mbewu mankhwalawa.
3. Pangani njira ya GMP (Good Manufacturing Practice) yopanga ndi kudzaza mankhwala okhala ndi zinthu.
4. Ikani mapepala ofunikira kuti muyese gawo loyamba la kukonzekera pakamwa.

Zolinga zonse zomwe zili pamwambazi ndizotheka mu projekiti yazaka ziwiri chifukwa 1) adakonza zoyambira zaukadaulo wa gel opopera, ndi 2) adapanga njira za GMP kuti apange zinthu zomwe tikufuna kugwiritsa ntchito kupopera mbewu mankhwalawa. Kuphatikiza apo, apanga kale kuyesa kwa biocompatibility kwa zinthuzo mogwirizana ndi ISO 10993 (muyeso wamakampani pakuyesa kwachilengedwe, kasamalidwe ka zoopsa ndi kuunika), ndipo ayesa kukhudzana ndi anthu pakhungu lomwe silili bwino. Onse akupangitsa kugwiritsa ntchito zokonzekera mu nthawi yochepa.

Cholinga cha polojekitiyi ndi kupanga mankhwala atsopano omwe angathandize kupewa zipsera mkamwa zomwe anthu ambiri a mdera la EB amakumana nazo potsatira kudya, kumwa, kapena kutsuka mano. Tikufuna kuti utsiwo uzitha kufalikira bwino pamalopo, ndiyeno kumamatira mkati mwa kamwa, m'malo mothamanga molunjika. Izi zidzalola kuti ma anti-scarring mamolekyu agwire ntchito yawo moyenera.

Tawonetsa kuti mtundu wa molekyulu yotchedwa polysaccharides, yomwe imachitika mwachilengedwe ndipo nthawi zambiri imaphatikizidwa muzakudya, imawonetsa mphamvu yamphamvu yotsutsa-fibrotic, yomwe yamphamvu kwambiri ndi carrageenan, yomwe imapezeka m'madzi am'nyanja. Kuti tichite izi, tinakhazikitsa chitsanzo chomwe timalima maselo a fibroblast (mtundu wa selo lomwe limapezeka pakhungu ndi mkati mwa mkamwa) mu mbale, ndikuwawonetsa ku molekyu yomwe imalimbikitsa mabala. Izi zimapangitsa kusintha kwakukulu mu fibroblasts, kuphatikizapo majini omwe amasonyeza, ndi mapuloteni omwe amapanga. Kenako tinayambitsa ma polysaccharides osiyanasiyana mu dongosolo, ndikuwonetsa ambiri a iwo amachepetsa majini ndi mapuloteni okhudzana ndi zipsera.

Tidawonetsanso kuti ma polysaccharides athu amatha kusokoneza mapangidwe a collagen - collagen yochulukirapo, yoyikidwa pansi mwachangu komanso yochulukirapo, ndizomwe zimapangitsa kuti chipsera chipangidwe. Ma polysaccharides athu ambiri adatha kuchepetsa mapangidwe a collagen fibril, kapena kuwaletsa kwathunthu.

Titawonetsa kuti carrageenan, polysaccharide yathu yothandiza kwambiri, inali molekyu yamphamvu yotsutsa mabala, tinayang'ana zinthu zakuthupi; timafuna kuti china chake chizipopera, koma chimakhala chokhuthala kapena cholimba ngati, chomwe chimamatira mkamwa kwa nthawi yayitali. Pamwamba kwambiri, mankhwala a carrageenan amakhala okhuthala, koma amapopera moyipa kwambiri. Chifukwa chake, tidayang'ana njira zowonjezerera kuthirira, ndikusunga makulidwe. Tinayang'ana njira ziwiri; kuphatikiza ndi polysaccharide yachiwiri, ndikugwiritsa ntchito mchere kuti musinthe mawonekedwe a carrageenan pang'ono. Tidawonetsa kuti kuphatikizika kwa polima kumawonjezera kutsekemera komanso kumamatira mkati mwa kamwa, ndipo imodzi mwamipangidwe yamchereyo idachulukitsanso malo opopera, komanso mafuta owonjezera. Izi ndizofunikira chifukwa zimachepetsa kukhumudwa kwapakamwa komwe kumayambitsa matuza ndipo pamapeto pake kumayambitsa mabala.

Tikuganiza kuti zipangizo zathu zatsopano, zomwe zimapopera ndi kumamatira mkati mwa kamwa, zingathandize kuchepetsa zipsera m'kamwa mwa anthu omwe ali ndi EB m'njira zitatu; kuyimitsa ma cell amkamwa kukhala ma cell owopsa, kuyimitsa kukhazikika kwa collagen mwachangu, ndikuthira mafuta kuti muchepetse kuvulala. Zidazi zimakhalanso ndi ubwino wambiri wobadwa nawo, monga mtengo wotsika mtengo, kukhazikika bwino kwa nthawi yaitali, chitetezo chodziwika (ambiri a iwo akhala akugwiritsidwa ntchito mu chakudya kwa zaka zambiri). Izi zimawapangitsanso kukhala osavuta kupanga ndikutsitsa mapaipi kupita ku mayeso azachipatala komanso kwa anthu, mwachiyembekezo kuti apititse patsogolo moyo wabwino mdera la EB. (Kuchokera ku lipoti lomaliza la 2022.)