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PhD: machiritso a zilonda mumitundu yonse ya EB (2024)
Kupanga katswiri watsopano wa EB kudzera mu maphunziro apamwamba, njira zasayansi zokhazikika za EB zimakhazikitsa nsanja ya kafukufuku wamtsogolo wa EB ndikulimbitsa maulalo achindunji pakati pa mautumiki azachipatala ndi zomangamanga zofufuzira.
Ndalamazi ndi zothandizira Dr Ajoy Bardhan pa maphunziro ake monga katswiri watsopano wa kafukufuku wa EB pa yunivesite ya Birmingham, UK, kumene adzayang'aniridwa ndi Prof Adrian Heagerty ndi akatswiri ena akuluakulu a EB. Ndikofunika kuphunzitsa akatswiri atsopano a EB kuti ntchito zofufuza zofunika, kuphatikizapo odwala ndi sayansi ya labotale, zipitirire kukula. Mapulojekiti a Dr Bardhan adzafufuza machiritso a zilonda mu mitundu yonse ya EB ndikuyang'ana zomwe zingatheke pazithandizo zochepetsera zipsera ndi khansa ku DEB.
Za ndalama zathu
| Mtsogoleri Wofufuza | Dr Ajoy Bardhan / Prof Adrian Heagerty |
| Malo | Yunivesite ya Birmingham, UK |
| Mitundu ya EB | Mitundu yonse ya EB |
| Kuleza mtima | palibe |
| Ndalama zothandizira | £125,263.24 |
| Kutalika kwa polojekiti | zaka 4 |
| Tsiku loyambira | September 2019 |
| ID yamkati ya DEBRA | Heagerty_Bardhan1 |
Tsatanetsatane wa polojekiti
Pulojekitiyi inasonkhanitsa zithupsa za khungu, madzi a chithuza ndi magazi kuchokera kwa anthu omwe ali ndi mitundu yosiyanasiyana ya EB, ndi anthu opanda EB poyerekeza. Ofufuzawo anayerekezera mabakiteriya ndi tizilombo tina timene timakhala pakhungu, mapuloteni a m’chithuza, ndi maselo oyera a m’magazi amene ali mbali ya chitetezo cha m’thupi.
Zotsatira zake zidawonetsa kuti khungu lovulazidwa la EB lili ndi mabakiteriya omwe amatha kuwononga komanso ma virus ochepa omwe angakhale opindulitsa. Ochita kafukufuku adawonanso umboni wa maselo a chitetezo cha mthupi akukhala m'njira yomwe ingapangitse zizindikiro za EB kukhala zovuta kwambiri, ndi kusintha kwa mapuloteni omwe amachokera ku maselowa kukhala madzi a chithuza.
Zotsatirazi zikusonyeza kuti kulimbikitsa kukula kwa tizilombo tothandiza pakhungu kumatha kuchepetsa mabakiteriya omwe amachepetsa kuchira kwa bala. Komanso kuti mankhwala omwe alipo omwe amasintha momwe maselo a chitetezo cha mthupi amachitira akhoza kubwezeretsedwanso kuti achepetse zizindikiro za EB monga kuyabwa.
Zotsatira za polojekitiyi zidasindikizidwa m'magazini asayansi:
Dr Bardhan wagwirizana ndi asayansi otsogola pankhani ya biology ya mamolekyulu, kafukufuku wa microbiome, kutupa ndi ma proteinomics kuti apange njira zatsopano zofufuzira EB kudutsa madera osiyanasiyana kuphatikiza maphunziro a locomotion ndi anti-scarring therapeutics.
Dr Bardhan wakhala akutenga nawo mbali pazathu projekiti ya microbiome kumene zotsatira zochititsa chidwi zoyambirira zimasonyeza kuti mitundu yosiyanasiyana ya EB imatsogolera ku tizilombo tosiyanasiyana tomwe timakhala pakhungu zomwe zimasintha mosiyana pamene mabala ayamba kuchira. Kafukufuku waperekanso umboni wa mayankho a chitetezo chamthupi omwe angayambitse kuwonongeka m'malo mochiritsa mitundu ina ya EB.
Ndalamazi zathandiziranso ntchito zingapo zowonongeka pambuyo pa kukhazikitsidwa kwa gulu latsopano la kafukufuku wa EB ku Birmingham, onse ndi cholinga choyesera kumvetsetsa bwino EB ndi kupanga njira zatsopano zothandizira chithandizo kuti zithandize kupititsa patsogolo umoyo wa anthu omwe akhudzidwa.
Dr Bardhan adasindikiza a onaninso nkhani za EB mu 2020, a kalozera wodziwira matenda amtundu wapakhungu kwa asing'anga mu 2021 ndi a lipoti pa chibadwa chatsopano cha EBS mu 2022.
Ntchito yake idawonetsedwa mu 2021 ndi 2022:
Zabwino, zoyipa ndi zoyipa: kutupa kwa mabala a epidermolysis bullosa - 2021
Othandizira mu epidermolysis bullosa: cutaneous microbiome - 2022
Cicatricial junctional epidermolysis bullosa: gawo loyiwalika - 2022
Kukonzekera kwachisamaliro mu epidermolysis bullosa: prototype for wider dermatology - 2022
Dr Ajoy Bardhan BSc, MBBS, MRCP (UK) (Dermatology)
Dr Bardhan ndi Clinical Lecturer pa University of Birmingham ndi Honorary Consultant Dermatologist pa University Hospitals Birmingham NHS Trust. Kutsatira maphunziro a digiri yoyamba ku Imperial College London komanso maphunziro aukadaulo ku Cambridge, adasamukira ku Birmingham kukachita maphunziro apadera a Dermatology. Ntchito yake yoyamba inali pa Chipatala cha Solihull, komwe anabwerera kukachita chiyanjano ku EB mothandizidwa ndi ntchito yapadera yapadziko lonse yomwe inatsogoleredwa ndi Prof Heagerty, mothandizidwa ndi maphunziro a labotale ku DGEM, pansi pa Prof McLean. Zochitika zina mkati mwa EB zidabwera monga registrar ku Birmingham Children's Hospital. Amaphatikiza ntchito zachipatala ndi kafukufuku wofunikira wa sayansi wofufuza mbali zambiri za machiritso a zilonda mu EB, kupindula ndi malo abwino kwambiri, othandizira, ndi kuyang'anira kuchokera kwa Prof Chapple ndi Heagerty.
Prof Adrian HM Heagerty BSc (Hons), MBBS, MRCP, MD, FRCP
Wosankhidwa ngati Consultant Dermatologist ku Birmingham Skin Hospital ku 1995, mwayi unapezeka mu 1998 kuti ayambe dipatimenti yatsopano ya dermatology ku Solihull Hospital, gawo la Birmingham Heartlands Hospital ndipo tsopano University Hospitals Birmingham NHS Foundation Trust. Prof Heagerty ali ndi maulalo ndi gulu lofufuza mu Epidermolysis Bullosa ndi Pachyonychia Congenita. Mu ntchito yake monga wolembera wamkulu, adatha kuzindikira mabanja omwe ali ndi EB Simplex, (EBS) zomwe zinapangitsa kuti adziwe zomwe zinali zolakwika mu EBS. Kuphatikizidwa ndi ntchito ya Junctional and Dystrophic forms of EB, ndipo pomalizira pake monga mtsogoleri wa NHS England theka la utumiki wa anthu akuluakulu a odwala oterowo, Prof Heagerty adatha kugwira ntchito limodzi ndi Prof McLean, ku yunivesite ya Dundee, kufufuza njira zamakono zolepheretsa majini. mawu, pogwiritsa ntchito chitsanzo cha EB ngati paradigm. Prof Heagerty anasankhidwa kukhala Pulofesa Wolemekezeka wa Dermatology ku yunivesite ya Birmingham, ndi magawo mu Institute of Inflammation and Ageing, akugwira ntchito ndi Prof Chris Buckley, Kennedy Pulofesa wa Rheumatology, kuti afufuze kuyambika kwa Psoriasis ndi Psoriatic Arthropathies, komanso Prof Janet. Lord ndi anzake akuwunika mayankho otupa komanso zipsera mu Dystrophic Epidermolysis Bullosa.
"Ngakhale kafukufuku wambiri akupitilirabe pazamankhwala opangira ma gene, gulu la EB lazindikira bwino kuti machiritso a zilonda ndi gawo lofunikira kwambiri pomwe kupita patsogolo kwa kafukufuku wa sayansi kutha kumasuliridwa mwachangu komanso mwachangu kuti pakhale kusintha kwa moyo wa odwala, mwa kuchepetsa kutupa, mabala ndi fibrosis. Tili ndi mwayi ku Birmingham tsopano kukhala ndi malo angapo operekedwa kuti afufuze ndi kukonza njira zomwezi, ndipo kukhazikitsidwa kwa maulalo pakati pa ofufuza apamwamba padziko lonse, chipatala cha EB ndi gulu la EB layamba kubala zipatso ndipo mwachiyembekezo zidzabweretsa zenizeni. zabwino kwa odwala athu posachedwapa. "
– Dr Ajoy Bardhan
Mutu wa Grant: DEBRA Clinical Fellow
Kupangidwa kwa malo atsopano a Academic Dermatology ku yunivesite ya Birmingham kudzakhazikitsa njira yopangira mapulogalamu atsopano ofufuza omwe akuyembekezeredwa kuti apindule ndi kupititsa patsogolo chithandizo chachipatala kwa odwala omwe ali ndi EB pakatikati, makamaka kugwiritsa ntchito mwayi wopita patsogolo pa kutupa. kafukufuku ndi kuchepetsa ndi kupewa zipsera, kuonetsetsa momveka bwino ndi kupitiriza kuganizira EB m'tsogolo.
Prof Adrian Heagerty, Adult EB Lead pa Solihull Hospital, pamodzi ndi Prof Iain Chapple, Pulofesa wa Periodontology ndi Restorative Dentistry ku University of Birmingham adzakhala oyang'anira Dr Ajoy Bardhan pamene akupanga chiphunzitso chake cha MD chofufuza mbali zingapo za machiritso a zilonda mu EB. Kuphatikizira ntchito zachipatala ndi kafukufuku woyambira wa sayansi kumamupatsa chidziwitso chothandizira kuti agwire ntchito yamtsogolo yoyang'ana odwala komanso maphunziro ku EB. Dr Bardhan adzagwira nawo ntchito zosiyanasiyana ndi Institute of Inflammation and Aging and Institute of Clinical Sciences. Yunivesite ya Birmingham posachedwapa yakhazikitsa Center for Scar Research, kufufuza njira zatsopano zothandizira kuchepetsa zipsera, ndi Institute of Bioengineering ikupanga njira zatsopano zoperekera. Sukulu ya Zamasewera, Zolimbitsa Thupi ndi Kukonzanso Sayansi ilinso ndi chidwi chofufuza njira zopititsira patsogolo moyo wa EB.
Mapulojekiti m'malo onsewa adzapatsa Dr Bardhan chidziwitso chokwanira pa kafukufuku wamakono wa EB. Adzayang'aniridwanso ndi Pulofesa Logan, Metcalfe ndi Grover mkati mwa Institute of Bioengineering ku yunivesite ya Birmingham ndi kuyang'aniridwa ndi Dr Lisa Hill, omwe adzathandiza Dr Bardhan pofufuza zipsera, machiritso a zilonda ndi khansa pogwiritsa ntchito chitsanzo mu labotale, ndi Drs Melissa Grant, Sarah Kuehne ndi Josefine Hirschfield pofufuza kuyanjana kwa ma microbial-immune mu mabala a EB.
DEBRA ikuthandiza kale pulojekiti ndi Prof Chapple (Maonekedwe a khungu la microbiome ndi kufufuza ntchito ya neutrophil mu Epidermolysis Bullosa odwala) ndipo Dr Bardhan adzamaliza mwakhama kufufuza kwa maselo a minofu monga gawo la polojekitiyi, kuti awonetserenso momwe kutupa kumayankhira.
Dr Bardhan adzalembedwanso ntchito kudzera ku Institute of Clinical Science ngati Clinical Lecturer/Honorary Consultant Dermatologist mu dipatimenti ya Dermatology pa Chipatala cha Solihull, omwe amagwira ntchito zadermatology ndi EB zothandizidwa ndi NHS.
Cholemetsa chachikulu cha EB ndi chifukwa cha mabala opitirira komanso obwerezabwereza omwe amachedwa kuchira, omwe ali pachiopsezo chotenga matenda, amagwirizana ndi ululu ndi kuyabwa, ndipo amafuna kuvala nthawi yayitali. Kuchiritsa kwachilonda panthawi yake ndikubwezeretsanso magwiridwe antchito akhungu kumadalira momwe chitetezo cha mthupi chimagwirira ntchito, chomwe sichimangochotsa tizilombo toononga (monga mabakiteriya, ma virus ndi bowa) pakhungu, komanso kuchotsa ndi kukonzanso. minofu yakufa. Komabe, si ma bacteria onse apakhungu omwe amawononga, ndipo tizilombo toyambitsa matenda 'abwino' titha kukhala ofunikira pa thanzi la khungu komanso kuthandizira ndi kuphunzitsa chitetezo cha mthupi. Chikhalidwe chenicheni cha tizilombo toyambitsa matenda pakhungu m'magulu osiyanasiyana a EB sichidziwikabe, komanso kuyankha kwa chitetezo cha mthupi mu mabala a EB sikudziwika. Kusayankha bwino komanso/kapena kuchulukitsa chitetezo cha m'thupi kungayambitse kuchila kwachilonda, kapena kukhalapo kwa tizilombo tambiri "oyipa" komanso osakwanira ma virus "abwino". Sizikudziwikanso ngati ma virus omwe amapezeka pakhungu amapangitsa kuti chitetezo cha mthupi chitetezeke, kapenanso, kuyankha kwa chitetezo chamthupi kumatengera ma virus omwe amakhala pakhungu.
Tatenga ziphuphu zapakhungu za anthu omwe ali ndi mitundu yosiyanasiyana ya EB pamalo opangira matuza atsopano, ndipo pa maola a 48, kuti tifufuze momwe tizilombo toyambitsa matenda timasinthira kumayambiriro kwa machiritso. Tayesanso madzi a chithuza kuchokera ku matuza atsopano, ndikutenga magazi kwa odwala nthawi yomweyo kuti tifufuze momwe maselo a chitetezo cha mthupi adayankhira kuvulala, komanso mapuloteni omwe ali m'madzi a blister (omwe amasonyeza ntchito ya maselo. pa malo ovulala). Tasankha kufufuza zochitika zoyambirira za machiritso a chilonda, chifukwa izi zidzakhudza zochitika zapatsogolo pa kuchira kwa bala. Pozindikira njira zowononga zoyambilira, tikuyembekeza kuti tidzatha kuzindikira zomwe tikufuna kusintha ndikuwongolera ntchito yochiritsa mabala.
Zotsatira zochititsa chidwi zikuwonetsa kuti khungu la EB limachulukitsa kuchuluka kwa ma virus omwe angawononge pakhungu koyambirira kwa machiritso a chilonda, komanso amasintha mosiyana pakuyankhidwa koyambirira kwa machiritso. Palinso tizilombo tomwe timatha kuteteza. Izi sizinawonetsedwepo m'mabala oyambirira a EB. Tawonanso umboni wa mayankho owonjezera a chitetezo chamthupi omwe angayambitse kuwonongeka kwa minofu m'malo mochiritsa makamaka ma subtypes a EB. Ntchito yowonjezereka ikufunika kuti tifufuze chifukwa chake ndi momwe izi zingakhalire, komanso kuti athe kuzindikira zolinga zatsopano zomwe zingatheke pazamankhwala omwe angathandize kukonza zosintha zomwe zangodziwika kumene pofuna kupititsa patsogolo machiritso kwa anthu omwe ali ndi EB.
Chofunika kwambiri, thandizoli lathandiziranso mapulojekiti angapo osinthika pambuyo pa kupangidwa kwa gulu latsopano la kafukufuku wa EB ku yunivesite ya Birmingham, onse ndi cholinga chofuna kumvetsetsa bwino EB ndi kupanga njira zatsopano zothandizira anthu kuti athandize kukhala ndi moyo wabwino. kwa omwe akhudzidwa.