Pitani ku nkhani

Zofalitsa zathu zofufuza

Mayi wina waima pakati pa mizere ya madirolo a makadi, akuŵerenga bukhu lalikulu, ndi mabuku angapo otsegula ndi otsekedwa patebulo patsogolo pake.

Zotsatira zafukufuku zosindikizidwa

Zotsatira za kafukufuku wothandizidwa ndi DEBRA UK zimasindikizidwa m'magazini asayansi omwe amawunikiridwa ndi anzawo, nthawi zambiri amatsagana ndi zolemba zomveka bwino kwa anthu wamba.

Kusindikiza m'magazini owunikiridwa ndi anzawo ndikofunikira chifukwa:

  • Imatsimikizira khalidwe la kafukufuku kudzera mu ndondomeko yowunikira akatswiri - ofufuza ena amafufuza mosamala zomwe zidachitika zisanasindikizidwe.
  • Timafalitsa chidziwitso ku gulu lalikulu la asayansi - chidziwitso chilichonse chatsopano chimathandizira kukulitsa kumvetsetsa kwathu kwa EB.
  • Amapanga kudalirika kwamaphunziro ndikuthandizira kupita patsogolo kwa ntchito - ofufuza athu, ndi ntchito yawo pa EB amadziwika bwino.
  • Amapanga mbiri yokhazikika, yodziwika bwino ya ntchitoyo - umboni womwe wasonkhanitsidwa ukhoza kutumizidwanso ndi ofufuza amtsogolo.
  • Imawonetsetsa kuti mfundo zamakhalidwe komanso akatswiri zikutsatiridwa - kuwunikanso anzawo ndikufalitsa kumawonetsetsa kuti pachitika zinthu poyera.

 

Kuvomereza ndalama kuchokera ku DEBRA UK:

Popereka kapena kusindikiza zotsatira, ndalama zochokera ku DEBRA UK ziyenera kuvomerezedwa ndi ofufuza athu pogwiritsa ntchito logo yathu ndi mawu: 

'Ndalama za - nambala yothandizira inapezedwa kuchokera ku DEBRA UK.'

Wofufuza Wamkulu atumize pdf ya mapepala onse osindikizidwa, zolembedwa pamanja ndi zolemba za msonkhano zokhudzana ndi Pulojekitiyi ku DEBRA UK nthawi yonse ya chithandizo komanso kwa zaka zisanu thandizo litatha. Zofalitsa zidzalembedwa pansipa:

Zofalitsa zochokera ku ndalama za DEBRA UK

DEBRA UK Project Kusindikiza kwasayansi Nkhani yachilankhulo chosavuta
Chithandizo cha majini chokhazikika cha RDEB (2026) Kusandutsa ma codon oletsa kusuta msanga kukhala mwayi wochiritsa  
Chithandizo cha cannabinoid pa ululu wonse wa EB ndi kuyabwa (2024) Tetrahydrocannabinol ndi cannabidiol zogwiritsira ntchito pochiza ululu mu epidermolysis bullosa: phunziro lopangidwa mwachisawawa, lolamulidwa ndi placebo  
PEBLES RDEB kafukufuku wazizindikiro (2022) Moyo wokhudzana ndi thanzi la munthu amene ali ndi vuto la recessive dystrophic epidermolysis bullosa: zomwe zapezeka mu Prospective Epidermolysis Bullosa Longitudinal Evaluation Study (PEBLES) Akuluakulu omwe ali ndi RDEB amatha kusintha, amanena kuti moyo wawo ndi wabwino akamakula: Kafukufuku
PhD: kuchepetsa DEB/JEB zilonda zamaso Macrophage Extracellular Vesicles: Njira Zochiritsira Corneal Fibrosis mu Matenda Osowa  
PhD: kukonza kukonza khungu mu JEB O15 Kupititsa patsogolo kukonzanso khungu mu JEB poyang'ana integrin αvβ6  
DEBRA UK Project Kusindikiza kwasayansi Nkhani yachilankhulo chosavuta
Chithandizo cha majini chokhazikika cha RDEB (2026) Kampani ya Three: Uinjiniya wa majini atatu nthawi imodzi pogwiritsa ntchito mapuloteni a Cas orthologous  
Chithandizo cha majini chokhazikika cha RDEB (2026) Kodi tafika pati? Kuchokera pakumvetsetsa matenda a collagen mpaka kupititsa patsogolo njira zochiritsira  
Mapiritsi a Psoriasis opangidwanso ndi EBS Maphunziro otseguka a Multicentre Phase II kuyesa mphamvu ndi chitetezo cha apremilast mwa ana ndi akulu omwe ali ndi epidermolysis bullosa simplex generalised: study protocol for the EBULO Study Ovomerezeka psoriasis mankhwala apremilast kuti ayesedwe kwambiri EBS odwala
Kutsata ma gene a EBS (2025) Epidermolysis Bullosa Simplex yokhala ndi Pigmentation ya Mottled ndi Migratory Circinate Erythema: Distinct Subtypes kapena Continuum?  
Chithandizo cha majini chokhazikika cha DEB (2026) Kusintha kwakukulu kwa nyama zoyamwitsa: Kuchokera kulonjezano mpaka kuchitapo kanthu  
Madontho amaso amitundu yonse ya EB (2025) Kupanga kwa gellan hydrogel kumathandizira kupanga madontho am'maso a antifibrotic, opaka mafuta.  
Rigosertib ya RDEB SSC (2022) Kuchita bwino ndi Chitetezo cha Rigosertib mwa Odwala Omwe Ali ndi Recessive Dystrophic Epidermolysis Bullosa Associated Advanced/Metastatic Cutaneous Squamous Cell Carcinoma Traws ipititsa patsogolo mapulani a chitukuko cha rigosertib ku RDEB-SCC
PEBLES RDEB maphunziro azizindikiro (2022) Zochitika zazikulu kwambiri mu recessive dystrophic epidermolysis bullosa: zomwe zapezedwa mu kafukufuku wa PEBLES. Khansara, kumeza, kudyetsa kumakhala kofala kwambiri mu RDEB yovuta
DEBRA UK Project Kusindikiza kwasayansi Nkhani yachilankhulo chosavuta

Kuchiza DEB itch ndi ma stem cell (2022)

 Kuyankha kwa Th2 kumayendetsa kuyabwa mu dystrophic epidermolysis bullosa pruriginosa: kafukufuku wowongolera milandu.  

Kubwezeretsanso mankhwala oletsa mabala mu RDEB (2023)

 Histone deacetylase inhibition imachepetsa kukula kwa matenda oyendetsedwa ndi fibrosis mu recessive dystrophic epidermolysis bullosa.  

Malangizo a EB Clinical Practice

 Neonatal epidermolysis bullosa: malangizo azachipatala Kalozera wothandiza wa kasamalidwe ka epidermolysis bullosa m'masabata anayi oyamba amoyo

KEB ndi khansa yapakhungu (2024)

 Kuphatikizidwa kwa Kindlin-1 mu cutaneous squamous cell carcinoma  

PEBLES RDEB maphunziro azizindikiro (2022)

 Ululu mu recessive dystrophic epidermolysis bullosa (RDEB): zopeza za Prospective Epidermolysis Bullosa Longitudinal Evaluation Study (PEBLES) Kupweteka kofala, koma kovuta kuwongolera, mu RDEB: kuphunzira

Kuchiza kwa majini kosatha kwa RDEB

 Njira zochiritsira zamtundu wapamutu pogwiritsa ntchito lipid nanoparticles: 'ma gene creams' a matenda apakhungu? 'Gene creams' kwa matenda amtundu

Kuchiza kwa majini kosatha kwa RDEB

 Lipid Nanoparticles Moyenera Kupereka Base Editor ABE8e kwa COL7A1 Kuwongolera mu Dystrophic Epidermolysis Bullosa Fibroblasts Mu Vitro  

Khungu la microbiome la mitundu yonse ya EB (2023)

Kuchiritsa mabala mumitundu yonse ya EB (2023)

 Kulumikizana kwa Genotype-phenotype mu Junctional Epidermolysis Bullosa: zikwangwani mpaka kuuma Kusintha kwapadera kwa JEB kumafotokoza kusiyanasiyana kwachipatala, ziwonetsero za kafukufuku
Kumvetsetsa matenda a airway mu JEB (2023) Za LAMA3 ndi LAMB3: Njira yatsopano yochizira epidermolysis bullosa (Ndemanga za ntchito yosindikizidwa mu 2024)  
Kumvetsetsa matenda a airway mu JEB (2023) Lentiviral chiwonetsero cha wildtype LAMA3A amabwezeretsa maselo adhesion mu airway basal maselo kuchokera ana ndi epidermolysis bullosa Njira yothandizira ma cell ndi majini ikuwonetsa lonjezo kwa ana a EB
Kuchepa mu RDEB (2023) Ma Gamma-Secretase Inhibitors Amachepetsa Njira Yozindikiritsa ya Profibrotic NOTCH mu Recessive Dystrophic Epidermolysis Bullosa. Kutsekereza njira yosainira ya NOTCH kumatha kuchepetsera zipsera za RDEB: Phunziro
DEBRA UK Project Kusindikiza kwasayansi Nkhani yachilankhulo chosavuta
Mitundu ya Modifer mu JEB (2017) Zosintha zisanu ndi ziwiri mwachilengedwe zimakhala ngati zosintha ma genetic a Lamc2jeb induced non-Herlitz junctional Epidermolysis Bullosa mu mbewa.  
PEBLES RDEB maphunziro azizindikiro (2022) Kuyabwa mu recessive dystrophic epidermolysis bullosa: zomwe zapezedwa ndi PEBLES, kafukufuku woyembekezeredwa kulembetsa. Kuyabwa kumakhala kofala mu RDEB - chithandizo chomwe chilipo sichithandiza kwambiri
PEBLES RDEB maphunziro azizindikiro (2022) Mtengo wa chisamaliro cha anthu aku UK kwa anthu omwe ali ndi recessive dystrophic epidermolysis bullosa: Zotsatira za Prospective Epidermolysis Bullosa Longitudinal Evaluation Study.  
Kuchiritsa mabala mumitundu yonse ya EB (2023) IgA nephropathy mwa akulu omwe ali ndi epidermolysis bullosa  
Kuchiritsa mabala mumitundu yonse ya EB (2023) Kodi kuchuluka kotsimikizika komwe kulipo kwa epidermolysis bullosa kukuwonetsa kulemedwa kwa matenda mwa odwala omwe ali ndi epidermolysis bullosa simplex?  
Kukhudzidwa kwa chitetezo chamthupi mu RDEB (2023) Kuyambitsa kotupa-mediated fibroblast activation ndi kuwonongeka kwa chitetezo chamthupi mu khungu lopanda collagen VII Kutupa mu RDEB kungalimbikitse kukula kwa khansa yapakhungu 
Kuchiritsa mabala mumitundu yonse ya EB (2023) 967 Kusintha kwa Spatiotemporal kwamagulu ang'onoang'ono pamagulu osiyanasiyana a machiritso a bala mu epidermolysis bullosa  
Kuchiritsa mabala mumitundu yonse ya EB (2023) BG05 Kuneneratu kwanzeru Zopanga za splice site mutatation mu junctional epidermolysis bullosa: zikwangwani mpaka kuuma  
Kuchiritsa mabala mumitundu yonse ya EB (2023) BG06 Pambuyo pa keratin: pamene simplex siili yophweka  

 

DEBRA UK Project Kusindikiza kwasayansi
Utsi pa RDEB gene therapy (2022) Kuthekera kwa chithandizo cha jini cha recessive dystrophic epidermolysis bullosa
Maselo a chitetezo chamthupi ndi mabala a RDEB (2022) Udindo wa mTOR Signaling Cascade mu Epidermal Morphogenesis ndi Skin Barrier Formation
Kuyenda ndi EBS (2022) P35: Kusintha kwa mphamvu zomwe zimagwiritsidwa ntchito pansi pa mapazi kwa odwala omwe ali ndi epidermolysis bullosa simplex panthawi yoyenda.

Kuyenda ndi EBS (2022)

Kuchiritsa mabala mumitundu yonse ya EB (2023)

 488 Ground reaction forces (GRF) mwa odwala omwe ali ndi epidermolysis bullosa simplex (EBS) poyenda
Utsi pa RDEB gene therapy (2022) Kuwunika mwadongosolo kwa anthu omwe ali ndi genotype-phenotype correlations mu recessive dystrophic epidermolysis bullosa (RDEB)
Utsi pa RDEB gene therapy (2022) Kubwezeretsa mtundu VII collagen pakhungu
Cannabinoid chithandizo cha ululu wonse wa EB ndi kuyabwa Kafukufuku wa C4EB-Transvamix (10% THC / 5% CBD) kuti athetse ululu wosatha mu epidermolysis bullosa: ndondomeko yofufuza mwachisawawa, yoyendetsedwa ndi placebo, ndi kafukufuku wapawiri wakhungu.
Kuchiritsa mabala mumitundu yonse ya EB (2023) Localized autosomal recessive epidermolysis bullosa simplex yochokera ku novel homozygous frameshift mutation mu DST (BPAG1)
Kuchiritsa mabala mumitundu yonse ya EB (2023) P17: Kukonzekera kwachisamaliro mu epidermolysis bullosa: chitsanzo cha dermatology.
Kuchiritsa mabala mumitundu yonse ya EB (2023) BG11: Kukwapula pamwamba: kubwerezabwereza kwa mawonekedwe a ophthalmological mu epidermolysis bullosa.
Kuchiritsa mabala mumitundu yonse ya EB (2023) BG12: Cicatricial junctional epidermolysis bullosa: subtype yoiwalika
Kuchiritsa mabala mumitundu yonse ya EB (2023) LB978 Kuchuluka kwa ma bacillales kumalumikizidwa ndi epidermolysis bullosa (EB) pamagawo osiyanasiyana a machiritso a bala.
Kuchiritsa mabala mumitundu yonse ya EB (2023) P33: Othandizira mu epidermolysis bullosa: cutaneous microbiome

 

DEBRA UK Project Kusindikiza kwasayansi Nkhani yachilankhulo chosavuta
Kuchiza DEB itch ndi ma stem cell (2022) Kukula, pathophysiology ndi kasamalidwe ka itch mu epidermolysis bullosa  
Kuchiza DEB itch ndi ma stem cell (2022) Mbiri ya Transcriptomic ya recessive dystrophic epidermolysis bullosa khungu lovulala likuwonetsa mwayi wogwiritsanso ntchito mankhwala kuti apititse patsogolo kuchira. Methotrexate ikhoza kuthandizira kuchiritsa khungu mu RDEB, kafukufuku akuwonetsa
Maselo a chitetezo chamthupi ndi mabala a RDEB (2022) Kuwongolera Mayankho Ochiritsa Mabala pa Ukalamba  
Maselo a chitetezo chamthupi ndi mabala a RDEB (2022) Kagayidwe ka Mitochondrial imagwirizanitsa njira zokonzetsera siteji mu macrophages panthawi yakuchira kwa bala  
Chithandizo chopopera pakamwa/pakhosi (2022) Low Acyl Gellan Monga Wothandizira Kuti Apititse patsogolo Kuthirira ndi Mucoadhesion wa Iota Carrageenan mu Utsi Wa M'mphuno Kuti Mupewe Kutenga Matenda Ndi SARS-CoV-2  
Utsi pa RDEB gene therapy (2022) Kuthekera kwa chithandizo cha jini cha recessive dystrophic epidermolysis bullosa  

Kubwezeretsanso mankhwala oletsa mabala mu RDEB

Kuchepa mu RDEB (2024)

 Chidziwitso chothandizira panjira zama cell akhungu fibrosis: yang'anani kwambiri panjira yozindikiritsa ya Notch.  
Kuchiritsa mabala mumitundu yonse ya EB (2023) Kuzindikira matenda akhungu  
Kuchiritsa mabala mumitundu yonse ya EB (2023) P45: Zabwino, zoyipa ndi zoyipa: kutupa kwa epidermolysis bullosa mabala  
Kuchiritsa mabala mumitundu yonse ya EB (2023) BG08: JEBseq: nkhokwe yatsopano kuti mufufuze kulumikizana kwa genotype-phenotype mu junctional epidermolysis bullosa

 

DEBRA UK Project Scientific Publication Chilankhulo Chosavuta
Malangizo a EB Clinical Practice Kusamalira phazi mu epidermolysis bullosa: malangizo ozikidwa pa umboni  
Maselo a chitetezo chamthupi ndi mabala a RDEB (2022) Glutamine Metabolism Imalamulira Stem Cell Fate Reversibility ndi Kusamalira Kwanthawi yayitali mu Follicle ya Tsitsi  
Khansara yapakhungu ya RDEB (2023) Chizoloŵezi chosasinthika cha kusintha kwa kukula kwa beta mu recessive dystrophic epidermolysis bullosa-yogwirizana ndi cutaneous squamous cell carcinoma.  
Kuchiritsa mabala mumitundu yonse ya EB (2023) Epidermolysis bullosa  

 

DEBRA UK Project Scientific Publication Chilankhulo Chosavuta
Maselo a chitetezo chamthupi ndi mabala a RDEB (2022) Epidermal mammalian chandamale cha rapamycin complex 2 chimayang'anira lipid synthesis ndi filaggrin processing mu epidermal chotchinga mapangidwe.  
Rigosertib ya RDEB SSC (2022) Kuzindikiritsa Rigosertib Pochiza Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma Rigosertib ikhoza kukhala yothandiza, yotetezeka ku squamous cell carcinoma mwa odwala a RDEB, kafukufuku akuwonetsa

 

 

Chizindikiro cha DEBRA UK. Chizindikirocho chimakhala ndi zithunzi za gulugufe wabuluu komanso dzina la bungwe. Pansi pake, mawu akuti "The Butterfly Skin Charity.
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