Khansara yapakhungu mu Kindler EB
Dzina langa ndine Dr Giovana Carrasco ndipo ndine wochita kafukufuku yemwe amagwira ntchito ku Edinburgh Cancer Research Center, Yunivesite ya Edinburgh. Ndikufufuza momwe kutayika kwa Kindlin-1, puloteni yomwe imakhudzidwa ndi momwe maselo amamatirirana ( cell adhesion ), imakhudzira kukula kwa mtundu wa khansa yapakhungu yotchedwa cutaneous squamous cell carcinoma.
Ndi mbali iti ya EB yomwe mumakonda kwambiri?
Kulandira majini osweka a Kindlin-1 kuchokera kwa makolo onse awiri kumatanthauza Kupanga kwa protein ya Kindlin-1 kumachepa kapena sikutheka konse ndipo anthu amakula opanda puloteni yofunika imeneyi m’matupi awo. Izi zimayambitsa chibadwa chotchedwa Kindler EB (KEB). Ntchito yanga zimachokera ku chidziwitso chakuti pali mwayi wowonjezereka wa odwala a KEB, kupanga mtundu waukali wa khansa yapakhungu yotchedwa cutaneous squamous cell carcinoma. Izi zikuphatikiza ndi zizindikiro za KEB za matuza ndi khungu lomwe limawotcha mosavuta.
Kodi ntchito yanu ipanga bwanji kwa anthu okhala ndi EB?
Tikuyembekeza kuti kafukufuku wathu adzatilola kukhala ndi a kumvetsetsa bwino za zoopsa zomwe odwala a KEB amakumana nazo pakukula matenda ena monga khansa. Ntchito yathu imatha kufotokozera momwe kutayika kwa Kindlin-1 kumapangitsa kuti khansa yapakhungu iyambe, kukula ndi kufalikira. Chidziwitso ichi chikanatero thandizani ofufuza mtsogolomo kuti apange chithandizo chamankhwala cha odwala a KEB ndi mtundu uwu wa khansa yapakhungu. Chochititsa chidwi n'chakuti, mwayi wowonjezereka wa kukula kwa chotupa kumatheka chifukwa cha kutaya kwa Kindlin-1 kumangowoneka pakhungu, kutaya kwake kumakhala ndi zotsatira zosiyana mu ziwalo zina. Kotero, palibe chophweka ndipo puloteni iyi, komanso kutenga nawo mbali mu khansa ya KEB, ndi malo osangalatsa kwambiri a kafukufuku.
Ndani / ndi chiyani chinakulimbikitsani kuti mugwire ntchito pa EB?
Chidwi changa chinayamba pokhala ndi wachibale yemwe ali ndi mtundu uwu wa khansa yapakhungu yomwe mwatsoka idangogwidwa pamlingo wapamwamba pamene imakhala ndi zotsatira zoipa. The pulojekiti mu labu ya Prof Brunton ndimakonda osati chifukwa kutayika kwa Kindlin-1 kumayambitsa matenda amtundu wa khungu, KEB, komanso chifukwa kumawoneka kuti ndi gawo lofunikira pakukula kwa khansa yapakhungu yamtunduwu. Maphunziro athu atha kutipangitsa kumvetsetsa bwino zomwe zimayambitsa khansa yamtundu uwu komanso zomwe zingatheke pezani njira zothanirana ndi khansa yapakhungu ya EB ndi machiritso atsopano kapena omwe alipo.
Kodi ndalama zochokera ku DEBRA zikutanthawuza chiyani kwa inu?
Ndife othokoza kwambiri kwa DEBRA chifukwa cha thandizo lomwe laperekedwa kuti tigwiritse ntchito kafukufuku wathu. Chifukwa cha iwo, takwanitsa kupititsa patsogolo ntchito yathu ndikupeza zatsopano zomwe tikukonzekera kufalitsa kuti asayansi ena apititse patsogolo kumvetsetsa kwathu. Ngakhale nkhani yathu yosangalatsa ikuwoneka yolunjika kwambiri, kumvetsetsa khansa imeneyi n'kogwirizana ndi nkhani zambiri zomwe tikufuna kuti tipitirize kuzifufuza.
Kodi tsiku m'moyo wanu ngati wofufuza wa EB likuwoneka bwanji?
Kawirikawiri, tsiku lililonse ndi losiyana. Timakonda kugwira ntchito mu labu pazoyeserera zathu ndikuwerenga kapena kulemba mu ofesi ya anthu. Zitha kukhala zotanganidwa pang'ono nthawi zina, makamaka chifukwa ndimakonda kuyesa kuyesa zingapo nthawi imodzi chifukwa zimandipangitsa kumva bwino ndikakhala ndi zotsatira zambiri kumapeto kwa tsiku. Ndimakonda kukhala ndi mndandanda wa zochita ndi ntchito zanga za tsiku ndi tsiku, kuphatikizapo kukonza zosakaniza zoyesera, kuwerengera ndi kukonza zida zokonzekera kusonkhanitsa zitsanzo, mwa zina. Zoyeserera zina zimatenga masiku angapo kuti zichitike, makamaka chifukwa amafuna kuti tikhazikitse zikhalidwe zama cell ndikuzisiya kuti zikule ndikuyankha chithandizo chathu. Tiyenera kusonkhanitsa zitsanzo kenako kupanga deta yomwe pambuyo pake timayisanthula ndikukonzekera kuti tikambirane ndi ofufuza athu akuluakulu. Kuchuluka kwa ntchito kumasiyanasiyana tsiku lililonse koma kupita patsogolo pang'ono tsiku ndi tsiku kumatifikitsa ku chithunzi chokulirapo cha zolinga zathu zazikulu.
Ndani ali pagulu lanu ndipo amachita chiyani kuti athandizire kafukufuku wanu wa EB?
Ndili m'gulu lalikulu la labu, lopangidwa ndi anthu azikhalidwe zosiyanasiyana omwe amagwira ntchito zosiyanasiyana zamakhansa. Timatsogoleredwa ndi ofufuza athu akuluakulu, Prof Margaret Frame ndi Prof Val Brunton, omwe ndi alangizi apamwamba ndipo amatilimbikitsa nthawi zonse mu kafukufuku wathu. Mamembala a labu ndi gulu lodabwitsa la anthu, ndipo tonse timagwirizana ndi kuthandizana. Ndikumva kuti ndili ndi mwayi wokhala m'gulu la labu la akatswiri komanso kukhala ndi malo ogwirira ntchito modabwitsa.
Kodi mumamasuka bwanji ngati simukugwira ntchito pa EB?
Munthawi yanga yopuma, ndimakonda kukhala panja ndi galu wanga, kuwonera makanema ndikuwerenga ndipo ndikufuna kupititsa patsogolo luso langa lojambula zojambulajambula, kumanga mipanda komanso kusewera piyano. Nthawi zonse ndimakhala wofunitsitsa kuphunzira zinthu zatsopano ndikuyesera zinthu zatsopano.